Hydrochloric Acid → HCID 118431685, compound

Participants

Reaction Steps

1-(2-Chloro-phenyl)-5-[4-(4-BOC-piperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (480.0 mg, 0.8 mmol) prepared in Example 311 was added to a saturated solution of hydrochloric acid in ethyl acetate (5.0 mL). The reaction mixture was stirred at room temperature for 2 hours and then concentrated under reduced pressure to give 450.0 mg of the titled compound as a pale yellow solid.

Provenance & Evidence