反应详情

温度

70 °C

5-(3′-Ethoxy-biphenyl-4-yl)-1-(2-fluoro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester (250.0 mg, 0.60 mmol) prepared in Step 1 and a solution of potassium hydroxide (67.0 mg, 1.19 mmol) in distilled water (4.0 mL) were added to methanol (4.0 mL). The reaction mixture was stirred at 70° C. for 2 hours and then concentrated under reduced pressure to discard methanol. The resulting residue was washed with diethyl ether, acidified by a 1N hydrochloric acid solution, and then extracted with ethyl acetate. The extract was washed with distilled water and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 200.0 mg of the titled compound as a pale yellow solid.

1. concentrationconcentrated under reduced pressure
2. washThe resulting residue was washed with diethyl ether
3. extractionextracted with ethyl acetate
4. washThe extract was washed with distilled water and brine
5. dry with materialdried on anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure