m-Chloroperbenzoic acid → HCID 118431895, compound

Participants

Reaction Steps

To a mixture of 1-(2-chloro-phenyl)-5-(3-fluoro-3′-methylsulfanyl-biphenyl-4-yl)-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole (31.0 mg, 0.06 mmol) prepared in Example 338 in dichloromethane (2.0 mL), was slowly added meta-chloroperbenzoic acid (77%, 22.8 mg, 0.12 mmol) at 0° C. The reaction mixture was stirred at room temperature for 2 hours, quenched with a saturated solution of sodium hydrogen carbonate, and then extracted with dichloromethane three times. The combined extract was washed with brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=2/1, 1/1) to give 5.0 mg of the titled compound as a yellow liquid.

Provenance & Evidence