Dimethylsulphamoyl chloride → HCID 118431724, compound

HRID 2208089Notes

Reaction equation

Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[N:10]1[CH:14]([C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:13][C:12]([C:27]([C:33]([F:36])([F:35])[F:34])([C:29]([F:32])([F:31])[F:30])[OH:28])=[N:11]1.[CH3:37][N:38]([CH3:43])[S:39](Cl)(=[O:41])=[O:40]>>[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[N:10]1[CH:14]([C:15]2[CH:16]=[CH:17][C:18]([N:21]3[CH2:22][CH2:23][N:24]([S:39](=[O:41])(=[O:40])[N:38]([CH3:43])[CH3:37])[CH2:25][CH2:26]3)=[CH:19][CH:20]=2)[CH2:13][C:12]([C:27]([C:29]([F:30])([F:32])[F:31])([C:33]([F:34])([F:35])[F:36])[OH:28])=[N:11]1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 118431989HCID 118431989, compound

Product 1

HCID 118431724HCID 118431724, compound

Procedure

The titled compound was prepared in accordance with the same procedures as in Example 406, except for using 1-(2,4-difluoro-phenyl)-5-[4-(piperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole hydrochloride prepared in Example 405; and using dimethylsulfamoyl chloride instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-d28b5d315f2042a894da8b56097a921c
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376420B2

Reaction notes

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