Dimethylsulphamoyl chloride → HCID 118431994, compound

HRID 2208093Notes

Reaction equation

Cl.[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[N:10]1[CH:14]([C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:13][C:12]([C:28]([C:34]([F:37])([F:36])[F:35])([C:30]([F:33])([F:32])[F:31])[OH:29])=[N:11]1.[CH3:38][N:39]([CH3:44])[S:40](Cl)(=[O:42])=[O:41]>>[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[N:10]1[CH:14]([C:15]2[CH:16]=[CH:17][C:18]([N:21]3[CH2:27][CH2:26][CH2:25][N:24]([S:40](=[O:42])(=[O:41])[N:39]([CH3:44])[CH3:38])[CH2:23][CH2:22]3)=[CH:19][CH:20]=2)[CH2:13][C:12]([C:28]([C:34]([F:35])([F:36])[F:37])([C:30]([F:31])([F:33])[F:32])[OH:29])=[N:11]1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 118431747HCID 118431747, compound

Product 1

HCID 118431994HCID 118431994, compound

Procedure

The titled compound was prepared in accordance with the same procedures as in Example 410, except for using 1-(2,4-difluoro-phenyl)-5-[4-(homopiperazin-1-yl)-phenyl]-3-[di-(trifluoromethyl)-hydroxy-methyl]-4,5-dihydro-1H-pyrazole hydrochloride prepared in Example 409; and using dimethylsulfamoyl chloride instead of methanesulfonyl chloride.

Sources & evidence

ORD record: ord-77401e306ade479f9273f5419b4bd369
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376420B2

Reaction notes

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