Trifluoroacetic acid → HCID 118432056, compound

Participants

Reaction Steps

To 5-{3′-[3-(N-BOC-N-methyl-amino)-propane-1-sulfonyl]-biphenyl-4-yl}-1-(2,4-difluoro-phenyl)-3-(di-(trifluoromethyl)-hydroxy-methyl)-4,5-dihydro-1H-pyrazole (23.0 mg, 0.03 mmol) prepared in Example 395, were added dichloromethane (0.5 mL) and trifluoroacetic acid (24.0 uL, 0.31 mmol). The reaction mixture was stirred at room temperature for 72 hours, washed with distilled water, 1N hydrochloride, a saturated solution of sodium hydrogen carbonate, and brine, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give 15.0 mg of the titled compound as a pale yellow liquid.

Provenance & Evidence