Formamidine acetate → HCID 178469266, compound

HRID 2208116Notes

Reaction equation

HRID 2208116 reaction equation
C(O[C:4]([C:6]1[NH:7][C:8]([CH3:17])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]=1[NH2:11])=[O:5])C.C(O)(=O)C.[CH:22](N)=[NH:23]>CCO>[CH2:15]([O:14][C:12]([C:9]1[C:10]2[N:11]=[CH:22][N:23]=[C:4]([OH:5])[C:6]=2[NH:7][C:8]=1[CH3:17])=[O:13])[CH3:16]

Participants

4

Reactant 2

HCID 160693Formamidine acetateHCID 67957125diethyl 3-amino-5-methyl-1H-pyrrole-2,4-dicarboxylate

Product 1

HCID 178469266HCID 178469266, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A reaction flask equipped with a mechanical stirrer, a reflux condenser and a nitrogen bubbler is charged with EtOH (5000 mL), 3-amino-5-methyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester from example A2 (565.57 g; 2.50 mol) and formamidine acetate (1041.10 g; 10.00 mol). The well-stirred reaction mixture is heated to gentle reflux for five days under an atmosphere of nitrogen.

Workup

  1. customA reaction flask equipped with a mechanical stirrer, a reflux condenser
  2. customThe well-stirred reaction mixture
  3. temperatureis heated
  4. temperatureto gentle reflux for five days under an atmosphere of nitrogen

Sources & evidence

ORD record
ord-3e591f00244d463683b5d72154741d77
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

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