HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-chloro-2,6-dimethyl-5H-pyrrolo[3,2-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2,6-Dimethyl-1H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | HCID 135725027 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-chloro-2,6-dimethyl-5H-pyrrolo[3,2-d]pyrimidine | HCID 18511061 | — |
Reaction Steps
2,6-Dimethyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one from example A6 (87.00 g; 0.53 mol) is suspended in dry acetonitrile (870 mL). After addition of POCl3 (122 mL; 1.33 mol) the stirred reaction mixture is heated to gentle reflux for 18 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376442B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b754c72b18af465496773706eb5b0444 |
| Source note | uspto-grants-2016_06 |