HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl[(1R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate → tert-butyl[(1R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl[(1R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate | HCID 131732233 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-butyl[(1R*,3R*,4R*)-4-amino-3-methylcyclohexyl]carbamate | HCID 131116877 | 93.2% |
Reaction Steps
tert-Butyl [(1R*,3R*,4R*)-4-azido-3-methylcyclohexyl]carbamate (example 010; 1.2 g; 4.7 mmol) is dissolved in MeOH (20.0 mL) and pressure hydrogenated over Pd (10% on charcoal; 0.1 g) at 20 bar and ambient temperature over night. After filtration through a pad of celite the solvent is removed under reduced pressure to yield 1.0 g of the title compound as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376442B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-9fda06db06ff4ad38ae76f856aaafaa3 |
| Source note | uspto-grants-2016_06 |