HCID 67033150, compound → HCID 67033067, compound

HRID 2208161Notes

Reaction equation

HRID 2208161 reaction equation
Cl[C:2]1[C:3]2[NH:10][C:9]([CH3:11])=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][C:21]=1B1OC(C)(C)C(C)(C)O1)[CH3:18]>>[CH2:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][C:21]=1[C:2]1[C:3]2[NH:10][C:9]([CH3:11])=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]=2[N:5]=[CH:6][N:7]=1)[CH3:18]

Participants

3

Reactant 2

HCID 67033150HCID 67033150, compoundHCID 86666646HCID 86666646, compound

Product 1

HCID 67033067HCID 67033067, compound

Procedure

Starting from ethyl 4-chloro-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example A4) and 2-(2-Ethoxy-5-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (example B.c10) the title compound is obtained as off-white solid.

Sources & evidence

ORD record
ord-f6b089cca6a242c3a3531d01baadfe56
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

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