HCID 67033218, compound → HCID 67956976, compound

HRID 2208165Notes

Reaction equation

HRID 2208165 reaction equation
Cl[C:2]1[C:3]2[NH:10][C:9]([CH3:11])=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]=2[N:5]=[CH:6][N:7]=1.[CH:17]1([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3([CH3:33])[O:32][CH2:31][CH2:30][O:29]3)=[CH:24][C:23]=2B2OC(C)(C)C(C)(C)O2)[CH2:19][CH2:18]1>>[CH:17]1([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3([CH3:33])[O:29][CH2:30][CH2:31][O:32]3)=[CH:24][C:23]=2[C:2]2[C:3]3[NH:10][C:9]([CH3:11])=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]=3[N:5]=[CH:6][N:7]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 67033218HCID 67033218, compoundHCID 86666646HCID 86666646, compound

Product 1

HCID 67956976HCID 67956976, compound

Procedure

Starting from ethyl 4-chloro-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example A4) and 2-[2-(cyclopropylmethoxy)-5-(2-methyl-1,3-dioxolan-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (example B.c13) the title compound is obtained as off-white solid.

Sources & evidence

ORD record
ord-48f87826c78e41d0a34ace3efa9b9acf
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

Loading…