HRID2208170

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1cc(B2OC(C)(C)C(C)(C)O2)c(OCC2CC2)cc1F

HCID66866377

2-(2-Cyclopropylmethoxy-4-fluoro-5-methoxy-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

C17H24BFO4

反应SMILES：COC(=O)c1c(C)n(COCC[Si](C)(C)C)c2c(Cl)nc(C)nc12

HCID86666640

methyl 4-chloro-2,6-dimethyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate

C16H24ClN3O3Si

PRODUCTS

产物

反应SMILES：COC(=O)c1c(C)n(COCC[Si](C)(C)C)c2c(-c3cc(OC)c(F)cc3OCC3CC3)nc(C)nc12

HCID67956280

未命名化合物

PROCEDURE

实验过程

Starting from methyl 4-chloro-2,6-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example A.11) and 2-(2-cyclopropylmethoxy-4-fluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane e (example B.c2) the title compound is obtained as off white solid.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-546c5760ab254daeb9a14879a2e63087
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09376442B2
来源说明: uspto-grants-2016_06

反应SMILES

Cl[C:2]1[C:3]2[N:11]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:10]([CH3:20])=[C:9]([C:21]([O:23][CH3:24])=[O:22])[C:4]=2[N:5]=[C:6]([CH3:8])[N:7]=1.[CH:25]1([CH2:28][O:29][C:30]2[CH:35]=[C:34]([F:36])[C:33]([O:37][CH3:38])=[CH:32][C:31]=2B2OC(C)(C)C(C)(C)O2)[CH2:27][CH2:26]1>>[CH:25]1([CH2:28][O:29][C:30]2[CH:35]=[C:34]([F:36])[C:33]([O:37][CH3:38])=[CH:32][C:31]=2[C:2]2[C:3]3[N:11]([CH2:12][O:13][CH2:14][CH2:15][Si:16]([CH3:19])([CH3:18])[CH3:17])[C:10]([CH3:20])=[C:9]([C:21]([O:23][CH3:24])=[O:22])[C:4]=3[N:5]=[C:6]([CH3:8])[N:7]=2)[CH2:26][CH2:27]1