2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 67956549, compound

HRID 2208179Notes

Reaction equation

HRID 2208179 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[C:14]1[C:15]2[NH:22][C:21]([CH3:23])=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:16]=2[N:17]=[CH:18][N:19]=1)[CH3:2].Cl[CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:12])([F:13])[F:11])=[CH:6][C:5]=1[C:14]1[C:15]2[N:22]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[C:21]([CH3:23])=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:16]=2[N:17]=[CH:18][N:19]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 67033067HCID 67033067, compound

Product 1

HCID 67956549HCID 67956549, compound

Procedure

Starting from ethyl 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate (example D.a9) and commercially available (2-chloromethoxy-ethyl)-trimethyl-silane the title compound is obtained as yellow viscous oil.

Sources & evidence

ORD record
ord-61b45ab48eca401abcc1750cfb713aa8
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

Loading…