反应详情

A solution of 2-chloro-4-hydroxy-benzonitrile (5.0 g, 32.6 mmol) in ethanol (125 ml) was treated with conc. sulphuric acid (25 ml) and the mixture heated at reflux for 3 days. Conc. sulphuric acid (25 ml) was added and the mixture was heated at reflux for another 2 days. The volatiles were removed in vacuo, and the aqueous residue was basified with saturated NaHCO3 and extracted 4 times with diethyl ether. The combined organic extracts were dried and concentrated in vacuo to yield the title compound (2.5 g, 38%).

1. temperaturethe mixture heated
2. temperatureat reflux for 3 days
3. temperaturethe mixture was heated
4. temperatureat reflux for another 2 days
5. customThe volatiles were removed in vacuo
6. extractionextracted 4 times with diethyl ether
7. customThe combined organic extracts were dried
8. concentrationconcentrated in vacuo