4-Amino-1-Boc-piperidine → HCID 67956678, compound

HRID 2208212Notes

Reaction equation

HRID 2208212 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[C:14]1[C:15]2[N:22]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[C:21]([CH3:31])=[C:20]([C:32](O)=[O:33])[C:16]=2[N:17]=[CH:18][N:19]=1)[CH3:2].[NH2:35][CH:36]1[CH2:41][CH2:40][N:39]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][CH2:37]1>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[C:14]1[C:15]2[N:22]([CH2:23][O:24][CH2:25][CH2:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[C:21]([CH3:31])=[C:20]([C:32]([NH:35][CH:36]3[CH2:37][CH2:38][N:39]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:40][CH2:41]3)=[O:33])[C:16]=2[N:17]=[CH:18][N:19]=1)[CH3:2]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 67033103HCID 67033103, compound

Product 1

HCID 67956678HCID 67956678, compound

Procedure

Starting from 4-[2-ethoxy-5-(trifluoromethyl)phenyl]-6-methyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.c9) and commercially available tert-butyl 4-amino-piperidine-1-carboxylate the title compound is obtained as pale yellow foam.

Sources & evidence

ORD record
ord-62cb9f9aeb444bdbb4d1187b49dfc0ae
Source dataset
uspto-grants-2016_06
Patent number
US09376442B2

Reaction notes

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