HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl (2S,4S)-4-amino-2-methylpyrrolidine-1-carboxylate → tert-Butyl(2S,4S)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-2-methylpyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl (2S,4S)-4-amino-2-methylpyrrolidine-1-carboxylate | HCID 22848096 | — |
| Reactant | 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid | HCID 67956012 | — |
| Product | tert-Butyl(2S,4S)-4-[({4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl}carbonyl)amino]-2-methylpyrrolidine-1-carboxylate | HCID 67955657 | — |
Reaction Steps
Starting from 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example D.g1) and commercially available tert-butyl (2S,4S)-4-amino-2-methylpyrrolidine-1-carboxylate the title compound is obtained as pale yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376442B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-939053d4c38c48f8b5f10fa67062e3db |
| Source note | uspto-grants-2016_06 |