HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(4-Methoxycarbonyl-butyl)-3-methyl-benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(4-Methoxycarbonyl-butyl)-3-methyl-benzoic Acid Tert-butyl Ester | HCID 57555333 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Methoxycarbonyl-butyl)-3-methyl-benzoic Acid | HCID 57555351 | 92% |
Reaction Steps
Trifluoroacetic acid (20 ml) was added to a solution of 4-(4-methoxycarbonyl-butyl)-3-methyl-benzoic acid tert-butyl ester from Example E31.3 (1.43 g, 4.7 mmol) in di-chloromethane (40 ml) and the mixture was stirred for 2 h at room temperature. Solvents were concentrated in vacuo and azeotroped with dichloromethane to yield the title compound (1.07 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-ee9f03a88a234524b626194affa8090b |
| Source note | uspto-grants-2012_06 |