Propionyl chloride → HCID 50992145, compound

HRID 2208292Notes

Reaction equation

Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=4[O:27][CH2:28][CH:29]4[CH2:31][CH2:30]4)[C:14]=3[NH:13][C:12]=2[CH3:32])=[O:10])[CH2:4][CH2:3]1.[C:33](Cl)(=[O:36])[CH2:34][CH3:35]>>[CH:29]1([CH2:28][O:27][C:21]2[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=2[C:19]2[C:14]3[NH:13][C:12]([CH3:32])=[C:11]([C:9]([NH:8][CH:5]4[CH2:4][CH2:3][N:2]([C:33](=[O:36])[CH2:34][CH3:35])[CH2:7][CH2:6]4)=[O:10])[C:15]=3[N:16]=[CH:17][N:18]=2)[CH2:30][CH2:31]1

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 67033816HCID 67033816, compound

Product 1

HCID 50992145HCID 50992145, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide hydrochloride (example D.f12) and commercially propionyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-ae1436b1e17942639f293ada02102850
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376442B2

Reaction notes

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