HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-(1,3-dioxolan-2-yl)piperidine-1-carboxylate → 4-(1,3-Dioxolan-2-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-(1,3-dioxolan-2-yl)piperidine-1-carboxylate | HCID 57555344 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1,3-Dioxolan-2-yl)piperidine | HCID 12725725 | 100% |
Reaction Steps
4-[1,3]Dioxolan-2-yl-piperidine-1-carboxylic acid benzyl ester from Example E33.3 (5.14 g, 17.7 mmol) was dissolved in methanol (100 ml) and hydrogenated over 10% Pd/C catalyst (551 mg) for 4 h. The mixture was filtered through Celite® filter agent and the filtrate was concentrated in vacuo to yield the title compound (2.84 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-606039bc37d34bcf9ba97b024e8ddac6 |
| Source note | uspto-grants-2012_06 |