N-Boc-N-[(1-Cbz-4-piperidyl)methyl]cyclopropanamine → tert-butyl N-cyclopropyl-N-[(piperidin-4-yl)methyl]carbamate

Participants

Reaction Steps

4-[(tert-Butoxycarbonyl-cyclopropyl-amino)-methyl]-piperidine-1-carboxylic acid benzyl ester from Example E38.2 (3.67 g, 9.4 mmol) was dissolved in methanol (100 ml) and hydrogenated over 10% Pd/C catalyst (3 g) for 1 h. The mixture was filtered through Celite® filter agent and the filtrate was concentrated in vacuo to yield the title compound (2.07 g, 87%).

Provenance & Evidence