Acetyl chloride → HCID 178475006, compound

HRID 2208416Notes

Reaction equation

Cl.[C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:31][CH2:32][CH:33]2[CH2:35][CH2:34]2)=[C:9]([C:11]2[C:12]3[NH:19][C:18]([CH3:20])=[C:17]([C:21]([NH:23][C@H:24]4[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]4)=[O:22])[C:13]=3[N:14]=[CH:15][N:16]=2)[CH:10]=1)(=[O:4])[CH3:3].[C:36](Cl)(=[O:38])[CH3:37]>>[C:36]([NH:30][C@H:27]1[CH2:28][CH2:29][C@H:24]([NH:23][C:21]([C:17]2[C:13]3[N:14]=[CH:15][N:16]=[C:11]([C:9]4[CH:10]=[C:5]([C:2](=[O:4])[CH3:3])[CH:6]=[CH:7][C:8]=4[O:31][CH2:32][CH:33]4[CH2:34][CH2:35]4)[C:12]=3[NH:19][C:18]=2[CH3:20])=[O:22])[CH2:25][CH2:26]1)(=[O:38])[CH3:37]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 178466783HCID 178466783, compound

Product 1

HCID 178475006HCID 178475006, compound

Procedure

Starting from 4-[5-acetyl-2-(cyclopropylmethoxy)phenyl]-N-(trans-4-aminocyclohexyl)-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide hydrochloride (example D.f56) and commercially available acetyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record: ord-bc820ef0c8d14d159a550dfb9b6ef9a8
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376442B2

Reaction notes

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