反应详情

4-{2-[4-(3,3-Dimethyl-butyl)-piperazin-1-yl]-ethoxy}-3-methyl-benzoic acid methyl ester from Example E40.3 (42 mg, 0.12 mmol) was dissolved in dioxan (5 ml) and 1M NaOH (1 ml) was added. The mixture was heated at reflux for 2 h then solvents were concentrated in vacuo. The residue was dissolved in EtOAc, washed with saturated NaHCO3, water then brine, dried and concentrated in vacuo to yield the title compound (40 mg, 100%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 h
3. concentrationsolvents were concentrated in vacuo
4. dissolutionThe residue was dissolved in EtOAc
5. washwashed with saturated NaHCO3, water
6. dry with materialbrine, dried
7. concentrationconcentrated in vacuo