HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Carboxymethoxy-3-methyl-benzoic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-tert-Butoxycarbonylmethoxy-3-methyl-benzoic Acid Methyl Ester | HCID 57555407 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Carboxymethoxy-3-methyl-benzoic Acid Methyl Ester | HCID 57555325 | 100% |
Reaction Steps
Trifluoroacetic acid (20 ml) was added to a solution of 4-tert-butoxycarbonylmethoxy-3-methyl-benzoic acid methyl ester from Example E41.1 (3.8 g, 13.6 mmol) in di-chloromethane (40 ml) and the mixture was stirred for 1 h at room temperature. Volatiles were removed in vacuo and azeotroped with dichloromethane to yield the title compound (3.04 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202858B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-213e6bd1296e41729536b74672aab7b8 |
| Source note | uspto-grants-2012_06 |