反应详情

A solution of 4-Amino-2-chloro-benzoic acid (5.3 g, 31 mmol) in methanol (100 ml) was treated with acetyl chloride (5 ml) and then heated at reflux for 16 hours. The solvents were evaporated in vacuo. The residue was dissolved in EtOAc, washed with saturated sodium hydrogen carbonate, dried and concentrated in vacuo to yield the title compound as a purple solid, 5.45 g, 95%.

1. temperatureheated
2. temperatureat reflux for 16 hours
3. customThe solvents were evaporated in vacuo
4. dissolutionThe residue was dissolved in EtOAc
5. washwashed with saturated sodium hydrogen carbonate
6. customdried
7. concentrationconcentrated in vacuo