huagongshe.com
HRID2208579

反应详情

EQUATION

反应方程式

HRID 2208579 的结构方程式

REACTANTS

反应物

2
结构：ClB(Cl)Cl
HCID25135

Boron trichloride

BCl3

结构：COc1c(C[C@H](NC(=O)c2ccc(CN(C)C)c(NC(=O)[C@@H](N)CNC(=O)OC(C)(C)C)c2)B2OC3CC4CC(C4(C)C)C3(C)O2)cccc1C(=O)OC(C)(C)C
HCID86725256

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)Cc1ccc(C(=O)N[C@H]2Cc3cccc(C(=O)O)c3OB2O)cc1NC(=O)[C@@H](N)CN
HCID76900772

未命名化合物

PROCEDURE

实验过程

Prepared from tert-butyl 3-((2R)-2-(3-((S)-2-amino-3-(tert-butoxycarbonylamino)propanamido)-4-((dimethylamino)methyl)benzamido)-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)ethyl)-2-methoxybenzoate and BCl3 following the procedure described in Step 2 of Example 3. The crude product was purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 470 (MH)+.

WORKUP

后处理

  1. customThe crude product was purified by reverse phase preparative HPLC
  2. customdried