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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2208585Generated: November 2, 2026

Hydrogen Bromide → 5-Bromoisoindoline

https://huagongshe.com/reaction/2208585

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrogen BromideHCID 260—
ReactantPhenolHCID 996—
ReactantPropionic AcidHCID 1032—
Reactant5-Bromo-2-(p-tolylsulfonyl)isoindolineHCID 15167898—
Product5-BromoisoindolineHCID 14795871—

Reaction Steps

To a solution of aqueous hydrobromic acid (16 mL, 48% solution in water), propionic acid (2.8 mL) and phenol (2 g) was added 5-bromo-2-(p-tolylsulfonyl)isoindoline (2.4 g, 6.8 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09376454B2
Source datasetuspto-grants-2016_06
ORD IDord-fbc84bc6c88c4201ae0bd2556ffc733a
Source noteuspto-grants-2016_06