HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Hydroxy-1-tetralone → oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Hydroxy-1-tetralone | HCID 119921 | — |
| Reactant | (-)-Epichlorohydrin | HCID 2734062 | — |
| Product | oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone | HCID 86748747 | — |
Reaction Steps
reacting 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone with (R)-(-)-epichlorhydrine, in an aprotic solvent in the presence of a strong base at a temperature of over 90° C., to give the intermediate chiral oxirane (S)-5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone with an optical purity greater than 95%, and then,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05426227 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-7d47044e2ac44991bb2f6c1fec64c091 |
| Source note | uspto-grants-1995_06 |