HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2208656Generated: October 30, 2026
Cyanoacetamide → 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
https://huagongshe.com/reaction/2208656
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1,1-Trifluoro-2,4-pentanedione | HCID 73943 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile | HCID 247440 | 52.5% |
Reaction Steps
To a solution of 2-cyanoacetamide (14.0 g, 166 mmol) and trifluoroacetylacetone (20.0 ml, 166 mmol) in H2O (332 ml) was added K2CO3 (6.60 g, 47.9 mmol). The mixture was stirred at 23° C. for 15 h. The precipitated solid was filtered with Buchner funnel, washed with ice cold H2O, and dried with hot air (60° C., 16 h) to give the titled compound (17.6 g, 52%). 1H NMR (400 MHz, DMSO-d6): δ ppm 2.38 (s, 3H), 6.66 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09376422B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-a044fbe07d6c44e9973aaa894834b161 |
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| Source note | uspto-grants-2016_06 |
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