Hydrochloric Acid → 3-{Ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoic acid

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 3-{ethyl[1-(propan-2-yl)piperidin-4-yl]amino}-2-methyl-5-(trifluoromethyl)benzoate (220 mg, 0.569 mmol) in methanol (4 mL) was added aq. NaOH (5M, 170 ul, 0.854 mmol). The reaction mixture was stirred at 50° C. for 2 hours. After cooling to 23° C. HCl (2 M) was added to the mixture. The mixture was acidified to pH=5 and was concentrated in vacuo to give the titled compound as crude products (510 mg).

Provenance & Evidence