反应详情

温度

80 °C

To a stirred solution of methyl 5-bromo-3-(cyclopentylamino)-2-methylbenzoate (0.5 g, 1.75 mmol) in acetonitrile (10 mL), Cs2CO3 (1.02 g, 2.63 mmol) and methyl iodide (1.45 g, 3.5 mmol) were added to it. The resulting reaction mixture was stirred at 80° C. for 4 h. Upon completion, the solvent was removed under reduced pressure and residue dissolved in water and extracted with ethyl acetate. Crude material obtained was purified by column chromatography over silica gel affording the desired compound product without further purification (0.39 g).

1. customThe resulting reaction mixture
2. customUpon completion, the solvent was removed under reduced pressure and residue
3. dissolutiondissolved in water
4. extractionextracted with ethyl acetate
5. customCrude material obtained
6. customwas purified by column chromatography over silica gel affording the desired compound product
7. customwithout further purification (0.39 g)