Methyl iodide → HCID 70873928, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-chloro-3-(cyclohexylamino)-2-methylbenzoate (1.4 g, 0.0049 mole) in acetonitrile (10 mL), cesium carbonate (3.2 g, 0.0099 mole) and methyl iodide (3.5 g, 0.0024 mole) were added; resulting reaction mass was heated at 80° C. for 13 h. On completion, reaction mass was cooled to room temperature and filtered, residue was washed with ethyl acetate and filtrate was concentrated and then purified by column chromatography to afford desired compound (800 mg, 55%).

Provenance & Evidence