Methyl iodide → HCID 86719536, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate (4 g, 9.09 mmol) in acetonitrile (50 mL), cesium carbonate (5.9 g, 18.09 mmol) and methyl iodide (6.95 g, 48.94 mmol) were added; resulting reaction mass was heated at 80° C. for 12 h. On completion, reaction mass was cooled to room temperature and filtered, residue was washed with ethyl acetate and filtrate was concentrated and then purified by column chromatography to afford the desired compound (2.2 g, 53%).

Provenance & Evidence