反应详情

温度

80 °C

To a stirred solution of methyl 2,5-dichloro-3-(cyclopentylamino)benzoate (0.275 g, 0.958 mmol) in acetonitrile (5 mL) was added cesium carbonate (0.622 g, 1.9 mmol) and methyl iodide (0.689 g, 4.78 mmol). The reaction mixture was heated at 80° C. for 18 h. On completion, the reaction was cooled to room temperature and filtered. The residue was washed with ethyl acetate and the filtrate was concentrated to afford methyl 2,5-dichloro-3-(cyclopentyl(methyl)amino)benzoate (0.27 g, 93%).

1. temperatureOn completion, the reaction was cooled to room temperature
2. filtrationfiltered
3. washThe residue was washed with ethyl acetate
4. concentrationthe filtrate was concentrated