Methyl iodide → HCID 70872433, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-bromo-3-((4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-2-methylbenzoate (1.5 g, 4.6 mmol) in acetonitrile (15 mL) was added cesium carbonate (2.63 g, 8.1 mmol) and methyl iodide (2.86 g, 20.32 mmol). The mixture was heated at 80° C. for 7 h. On completion, the reaction was cooled to room temperature, filtered, and the residue was washed with ethyl acetate. The filtrate was concentrated to afford methyl 5-bromo-3-((4-((tert-butoxycarbonyl)amino)cyclohexyl)(methyl)amino)-2-methylbenzoate (1.5 g).

Provenance & Evidence