反应详情

A solution of methyl 5-bromo-3-(cyclopentylamino)-2-methylbenzoate (1 g, 3.22 mmol), Cs2CO3 (2.10 g, 6.45 mmol) and methyl iodide (2.3 g, 16.12 mmol) in acetonitrile (15 mL) was heated at 80° C. for 14 h. After complete consumption of starting material reaction mixture was filtered. The filtrate was concentrated and the obtained residue was purified by column chromatography to provide the desired compound (0.9 g, 86%).

1. customAfter complete consumption of starting material reaction mixture
2. filtrationwas filtered
3. concentrationThe filtrate was concentrated
4. customthe obtained residue was purified by column chromatography