HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2208734Generated: November 1, 2026
Methyl iodide → 5-Bromo-1,2-dimethyl-3-nitrobenzene
https://huagongshe.com/reaction/2208734
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Bromo-2-methyl-3-nitrobenzoic acid | HCID 13770008 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-1,2-dimethyl-3-nitrobenzene | HCID 12381865 | 119% |
Reaction Steps
To stirred solution of 5-bromo-2-methyl-3-nitrobenzoic acid (287 g, 1103 mmol) in DMF (150 mL), sodium carbonate (468 g, 4415 mmol) and methyl iodide (626.63 g, 4415 mmol) were added. Resulting reaction mass was heated at 60° C. for 8 h. On completion, solid precipitated was filtered, residue washed with diethyl ether (5 times). Combined organic layers were dried, concentrated under reduced pressure giving the desired compound (302 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09376422B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-b555823127704e249834d9b9328407d6 |
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| Source note | uspto-grants-2016_06 |
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