Ammonium Chloride → Methyl 3-Amino-5-bromo-2-methylbenzoate

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-bromo-2-methyl-3-nitrobenzoate (17 g, 62.04 mmol) in ethanol (85 mL), was added NH4Cl solution (17 g in 85 mL water, 317.8 mmol) followed by Fe powder (27.82 g, 498.11 mmol). Resulting reaction mass was stirred at 90° C. for 1 h. On completion, reaction mass was filtered and filtrate was concentrated till dryness to get solid which was dissolved in saturated sodium bicarbonate solution. Aqueous layer was extracted with ethyl acetate. Combined organic layers were dried over sodium sulfate and concentrated to afford the desired compound (15 g, 99%).

Provenance & Evidence