反应详情

温度

-10 °C

5-Bromo-2,4-dimethylbenzoic acid (12 g, 52.17 mmol) was added to cooled conc. H2SO4 (48 mL) at −10° C. lot wise. After 10 minutes nitrating mixture {prepared as mixing Conc. HNO3 (6 mL) with conc.H2SO4 (24 mL)} was added drop wise at −10° C. Resulting reaction mass was stirred at −10° C. for 30 minutes. On completion, reaction mixture was poured on ice cold water, solid precipitated was filtered, washed with water and dried under vacuum giving desired compound (13 g, 91%).

1. custommixture {prepared
2. customResulting
3. customreaction mass
4. customOn completion, reaction mixture
5. additionwas poured on ice cold water, solid
6. customprecipitated
7. filtrationwas filtered
8. washwashed with water
9. customdried under vacuum