Methyl iodide → Methyl 5-chloro-2-methyl-3-nitrobenzoate

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-chloro-2-methyl-3-nitrobenzoic acid (23.5 g, 0.109 mmol) in DMF (120 mL) was added sodium carbonate (46.21, 0.436 mmol) and methyl iodide (27.2 mL, 0.43 mmol) at room temperature. The reaction mixture was heated at 60° C. for 3 h. After complete consumption of starting material the reaction mixture was filtered and the residue washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the crude product purified by column chromatography to provide the desired compound (16 g, 64%) as thick oil which solidified on standing.

Provenance & Evidence