反应详情

温度

80 °C

To a stirred solution of methyl 5-bromo-3-(cyclopentylamino)-2-methylbenzoate (1.6 g, 5.38 mmol) in acetonitrile (20 mL), cesium carbonate (3.5 g, 10.73 mmol) and methyl iodide (3.87 g, 27.25 mmol) were added and the resulting reaction mixture heated at 80° C. for 12 h. On completion, the reaction mixture was cooled to room temperature and filtered. The residue was washed with ethyl acetate and filtrate concentrated and purified by column chromatography to afford desired compound (1.6 g, 95%).

1. customthe resulting reaction mixture
2. temperatureOn completion, the reaction mixture was cooled to room temperature
3. filtrationfiltered
4. washThe residue was washed with ethyl acetate and filtrate
5. concentrationconcentrated
6. custompurified by column chromatography