Iodoethane → HCID 70913248, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-chloro-3-(cyclohexylamino)-2-methylbenzoate (1.2 g, 4.3 mmol) in dry DMF (15 mL), cesium carbonate (2.78 g, 8.5 mmol) and ethyl iodide (3.35 g, 21.47 mmol) were added. The resulting reaction mixture was heated at 80° C. for 18 h. On completion, the reaction mixture was cooled to room temperature and filtered, and the residue washed with ethyl acetate. The filtrate was concentrated and purified by column chromatography to afford methyl 5-chloro-3-(cyclohexyl(ethyl)amino)-2-methylbenzoate (0.25 g, 22.7%).

Provenance & Evidence