Acetic Acid → HCID 70873949, compound

Participants

Reaction Steps

To a stirred solution of methyl 3-amino-2-bromobenzoate (3 g, 13.01 mmol) and cyclopentanone (5.6 g, 66 mmol) in methanol (30 mL), acetic acid (1.59 g, 26.6 mmol) was added and the reaction stirred at room temperature for 3 h. Then sodium cyanoborohydride (2.08 g, 29.4 mmol) was added and the mixture stirred overnight. On completion, solvent was removed under reduced pressure and crude material was purified by column chromatography to afford methyl 2-bromo-3-(cyclopentylamino)benzoate (1.4 g, 36%).

Provenance & Evidence