Water → Methyl 5-chloro-2-methyl-3-nitrobenzoate

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 5-chloro-2-methyl-3-nitrobenzoic acid (6.75 g, 31.3 mmol) in DMF (33 mL), were added sodium carbonate (13.23 g, 125 mmol) and methyl iodide (17.77 g, 125 mmol). The mixture was heated at 60° C. for 4 h. On completion, water was added to the reaction mass and extraction was carried out using DCM. The combined organic layers were dried, concentrated under reduced pressure, and purified by column chromatography over silica gel (to afford the title compound (6.0 g, 83%).

Provenance & Evidence