Diisopropylethylamine → 5-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzamide

HRID 2208868Notes

Reaction equation

HRID 2208868 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:13]([CH2:20][CH3:21])[CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]([CH2:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C.[NH2:55][CH2:56][C:57]1[C:58](=[O:65])[NH:59][C:60]([CH3:64])=[CH:61][C:62]=1[CH3:63]>CN(C=O)C.CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:13]([CH2:20][CH3:21])[CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[C:5]([CH2:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH:55][CH2:56][C:57]1[C:58](=[O:65])[NH:59][C:60]([CH3:64])=[CH:61][C:62]=1[CH3:63])=[O:9]

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 70638443-(Aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-oneHCID 708722245-Chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid

Product 1

HCID 708722615-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzamideYield 63.1%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid (100 mg, 0.32 mmol) in DMF (2 ml) at room temperature under nitrogen was added HBTU (146 mg, 0.38 mmol) followed by N-ethyl-N-(propan-2-yl)propan-2-amine (84 μl, 0.48 mmol) and 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one (89%, 60.3 mg, 0.35 mmol). After stirring for 3 hours at room EtOAc (30 ml) was added to the reaction mixture and this was then washed with deionized water (5 ml) followed by saturated NaHCO3(aq) (3×5 ml). The organic phase was dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by FCC (5 g silica, Isolute cartridge, gradient of eluents; 100% EtOAc to 97:3 EtOAc:MeOH) to give 90 mg (63%) of the title compound as a white solid. LC-MS 97%, m/z=446.1/448.2, 1H NMR (500 MHz, Chloroform-d) δ ppm 11.93 (s, 1H), 7.14 (t, J=5.7 Hz, 1H), 7.10 (d, J=2.0 Hz, 1H), 7.04 (d, J=2.0 Hz, 1H), 5.95 (s, 1H), 4.52 (d, J=5.8 Hz, 2H), 3.95 (d, J=11.2 Hz, 2H), 3.30 (td, J=11.3, 3.6 Hz, 2H), 3.01 (q, J=7.0 Hz, 2H), 2.93 (ddd, J=15.3, 10.0, 5.3 Hz, 1H), 2.83 (q, J=7.4 Hz, 2H), 2.38 (s, 3H), 2.22 (s, 3H), 1.71-1.63 (m, 4H), 1.02 (t, J=7.5 Hz, 3H), 0.86 (t, J=7.0 Hz, 3H).

Workup

  1. additionwas added to the reaction mixture
  2. washthis was then washed with deionized water (5 ml)
  3. dry with materialThe organic phase was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by FCC (5 g silica, Isolute cartridge, gradient of eluents; 100% EtOAc to 97:3 EtOAc:MeOH)

Sources & evidence

ORD record
ord-8748856564794a50a64e7c4d778c3d84
Source dataset
uspto-grants-2016_06
Patent number
US09376422B2

Reaction notes

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