HCID 86719568, compound → HCID 70874407, compound

Participants

Reaction Steps

To a stirred solution of 3-(allyl(tetrahydro-2H-pyran-4-yl)amino)-5-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide (0.10 g) in MeOH (10 mL) was added 10% Pd/C (0.03 g) and the reaction stirred at room temperature under hydrogen (balloon pressure) for 2 h. On completion, the reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to obtain crude solid which was purified by column chromatography to afford the title compound (0.02 g, 20%). LCMS: 445.25 (M+1)+; HPLC: 90.40% (@ 254 nm) (Rt; 5.609; Method: Column: YMC ODS-A 150 mm×4.6 mm×5μ; Mobile Phase: A; 0.05% TFA in water/B; 0.05% TFA in acetonitrile; Inj. Vol: 10 μL, Col. Temp.: 30° C.; Flow rate: 1.4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1.5 min, 9.51-12 min 5% B); 1H NMR (DMSO-d6, 400 MHz) δ 11.47 (s, 1H), 8.23 (t, 1H), 7.19 (s, 1H), 6.93 (d, 1H, J=1.6 Hz), 5.88 (s, 1H), 4.24 (d, 2H, J=4.4 Hz), 3.83 (d, 2H, J=10.4 Hz), 3.22-3.25 (m, 2H), 2.94 (t, 2H, J=7.2 Hz), 2.88-2.90 (m, 1H), 2.18 (s, 3H), 2.15 (s, 3H), 2.10 (s, 3H), 1.56 (m, 4H), 1.14-1.23 (m, 2H), 0.75 (t, 3H, J=8 Hz).

Provenance & Evidence