Methyl iodide → HCID 86719569, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-chloro-3-(isobutyl amino)-2-methylbenzoate (1.0 g, 3.9 mmol) in dry acetonitrile (10 mL), cesium carbonate (2.55 g, 7.8 mmol) and methyl iodide (5.55 g, 39 mmol) were added. The mixture was heated at 80° C. for 12 h. On completion, the mixture was cooled to room temperature and filtered. The residue was washed with ethyl acetate and the filtrate was concentrated to the title compound (1.0 g, 95%).

Provenance & Evidence