Iodoethane → HCID 86719570, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-chloro-3-(isobutyl amino)-2-methylbenzoate (1.0 g, 3.9 mmol) in dry DMF (10 mL), cesium carbonate (2.55 g, 7.82 mmol) and ethyl iodide (6.09 g, 39.1 mmol) were added. The resulting reaction mass was heated at 80° C. for 12 h. On completion, the reaction mass was cooled to room temperature and filtered. The residue was washed with ethyl acetate and the filtrate was concentrated to give crude material which then used for next step as is (10 g, 91%).

Provenance & Evidence