Methyl iodide → HCID 86719572, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl 5-chloro-3-(cyclobutylamino)-2-methylbenzoate (0.7 g, 2.8 mmol) in acetonitrile-(10 mL), cesium carbonate (2.2 g, 6.8 mmol) and methyl iodide (3.9 g, 28 mmol) were added. The resulting reaction mass was heated at 80° C. for 8 h. On completion, the reaction mass was cooled to room temperature and filtered. The residue was washed with ethyl acetate and the filtrate was concentrated to give the title compound (0.62 g, 84%).

Provenance & Evidence