Acetic Acid → methyl 5-bromo-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzoate

Participants

Reaction Steps

To a stirred solution of methyl 5-bromo-2-methyl-3-((tetrahydro-2H-pyran-4-yl)amino)benzoate (14 g, 43 mmol) and acetaldehyde (3.75 g, 85 mmol) in dichloroethane (150 mL), was added acetic acid (15.4 g, 256 mmol) and the reaction stirred at room temperature for 20 minutes. Then sodium triacetoxyborohydride (27.0 g, 128 mmol) was added at 0° C. and the reaction stirred at room temperature for 2 h. The solvent was removed under reduced pressure and water added to the residue. Extraction was carried out using DCM and the combined organic layers were dried over sodium sulphate and concentrated under reduced pressure to give crude material was purified by column chromatography to afford the title compound (14 g, 93%).

Provenance & Evidence