Methyl iodide → Methyl 5-bromo-2-methyl-3-nitrobenzoate

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of crude 5-bromo-2-methyl-3-nitrobenzoic acid (287 g, 1103 mmol) in DMF (150 mL), sodium carbonate (468 g, 4415 mmol) and methyl iodide (626 g, 4415 mmol) were added. The mixture was heated at 60° C. for 8 h, cooled to room temperature. The solid precipitate was filtered and washed with diethyl ether (5 times). The combined organic layers were dried and concentrated under reduced pressure to give the title compound (302 g, 99%) which was used directly.

Provenance & Evidence